| 货号 | 5647/10 |
| 别名 | N-(2-Aminophenyl)-4-[(3,4-dihydro-4 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective HDAC2/3 inhibitor (IC50 values are 16 and 30 nM, respectively). Exhibits >250-fold selectivity for HDAC2/3 over other HDAC isoforms. Promotes apoptosis of leukemia cell lines in vitro. Also attenuates IL-6 production in rheumatoid arthritis PBMCs in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 383.44 |
| 分子式 | C24H21N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Boissinotet al (2012) Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk.Res. 36 1304. PMID: 22818799. Gillespieet al (2012) Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthrit.Rheumat. 64 418. PMID: 21952924. |