| 货号 | 3425/1 |
| 别名 | Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide |
| 供应商 | Tocris |
| 生物活性 | Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro(IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1981.33 |
| 分子式 | C94H145N23O24 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 143896-17-7 |
| 序列号 | GWTLNSAGYLLGPPPALALA (Modifications: Ala-20 = C-terminal amide) |
| 参考文献 | Luet al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102874. Yuanet al (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther. 301488. Bartfaiet al (1993) Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 9011287. |