| 货号 | 4783/10 |
| 别名 | 4-[(3,3-Dimethyl-1-oxobutyl)amino]- |
| 供应商 | Tocris |
| 生物活性 | Prodrug of a potent and selective adenosine A2A receptor antagonist (Ki values are 5.9, 260, 410 and <10,000 nM for A2A, A2B, A1 and A3 receptors respectively. Reverses parkinsonian motor impairment and motivational effects produced by dopamine D2 receptor blockade in rats. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 463.39 |
| 分子式 | C17H20F2N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Collinset al (2012) The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol.Biochem.Behav. 100 498. PMID: 22037410. Samset al (2011) Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA2A receptor antagonist. J.Med.Chem. 54 751. PMID: 21210664. |