| 货号 | 4745/10 |
| 别名 | N-[5-[1-(2,6-Dichlorophenyl)-3-(dif |
| 供应商 | Tocris |
| 生物活性 | Potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 431.29 |
| 分子式 | C17H14Cl2F2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Sparrowet al (2012) The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination. J.Neurosci. 32 5284. PMID: 22496574. Scottet al (2010) LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J.Cell Biol. 191 169. PMID: 20876278. Ross-Macdonaldet al (2008) Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol.Cancer Ther. 7 3490. PMID: 19001433. |