| 货号 | 1674/10 |
| 别名 | 6,7,8,9,14,15-Hexahydro-7-methyl-5H |
| 供应商 | Tocris |
| 生物活性 | Potent and selective dopamine D1 receptor antagonist (Ki values are 0.08 - 1.9 nM and 6 - 45 nM for D1 and D2 receptors respectively). Also displays moderate affinity for the 5-HT2A receptor (Ki = 20 nM). Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 290.41 |
| 分子式 | C20H22N2 |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO |
| CAS号 | 274694-98-3 |
| 参考文献 | El-Subbaghet al (2002) Dopamine/serotonin receptor ligands: Part IV [1]: Synthesis and pharmacology of novel 3-benzazecines and 3-benzazonines as potential 5-HT2A and dopamine receptor ligands. Arch.Pharm. (Weinheim). 9 443. PMID: 12447918. Kassacket al (2002) Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar dopamine receptor antagonist. Naunyn Schmiedebergs Arch.Pharmacol. 366 543. PMID: 12444495. Wittet al (2000) 7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for dopamine receptor antagonists. J.Med.Chem. 43 2079. PMID: 10821720. |