| 货号 | 1694/10 |
| 别名 | 2-Methyl-1-[2-(1-methylethyl)pyrazo |
| 供应商 | Tocris |
| 生物活性 | Phosphodiesterase inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 230.31 |
| 分子式 | C14H18N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 50847-11-5 |
| 参考文献 | Kishiet al (2001) Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc.Drug Rev. 19 215. PMID: 11607039. Sounesset al (1994) Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br.J.Pharmacol. 111 1081. PMID: 8032594. Nishinoet al (1983) KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis. Jpn.J.Pharmacol. 33 267. PMID: 6193303. |