| 货号 | 3014/500U |
| 别名 | Icatibant |
| 供应商 | Tocris |
| 生物活性 | Potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1304.52 |
| 分子式 | C59H89N19O13 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | RRPXGXSXXR (Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = Tic, X-9 = Oic) |
| 参考文献 | Bawolaket al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108. PMID: 17026984. Feletouet al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683. PMID: 8075888. Hocket al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769. PMID: 1364851. |