| 货号 | 5011/10 |
| 别名 | N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2, |
| 供应商 | Tocris |
| 生物活性 | Potent and selective Iks channel blocker (IC50 values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 411.44 |
| 分子式 | C17H24F3NO5< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Michaelet al (2007) Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation. Br.J.Pharmacol 152 1215. PMID: 17965747. Thomaset al (2003) HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J.Cardiovasc.Pharmacol. 41 140. PMID: 12500032. Gerlachet al (2001) Synthesis and activity of novel and selective I(Ks)-channel blockers. J.Med.Chem. 44 3831. PMID: 11689069. |