| 货号 | 1420/100U |
| 供应商 | Tocris |
| 生物活性 | Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent inhibitor of Ins (1,4,5)P3 5-phosphatase (IC50 ~150 nM); facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3 |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 804.73 |
| 分子式 | C6H8O18P4 |
| 可溶性/溶解性 | Soluble in water |
| 参考文献 | Hermosuraet al (2000) InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase. Nature 408 735. PMID: 11130077. Cullenet al (1998) Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. Biochim.Biophys.Acta 1436 35. PMID: 9838034. Ballaet al (1991) Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate. J.Biol.Chem. 266 24719. PMID: 1662215. |