| 货号 | 2255/10 |
| 别名 | 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-p |
| 供应商 | Tocris |
| 生物活性 | Calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 544.61 |
| 分子式 | C26H28N4O2.C4H4O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming |
| CAS号 | 109826-27-9 |
| 参考文献 | Liet al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195. PMID: 12419798. Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183. PMID: 1379190. Normanet al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 31 535. PMID: 3033469. |