| 货号 | 3536/1 |
| 供应商 | Tocris |
| 生物活性 | Potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1491.11 |
| 分子式 | C70H92CIN17O14.C2H4O2 |
| 可溶性/溶解性 | Soluble in water |
| CAS号 | 120287-85-6 |
| 序列号 | XFASYXLRPA (Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide) |
| 参考文献 | Telegdyet al (2009) Effects of the LHRH antagonist cetrorelix on the brain function in mice. Neuropeptides 43 229. PMID: 19375162. Grundker and Emons (2003) Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 1 65. PMID: 14594454. Beckerset al (1997) Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 251 17. PMID: 9300077. |