| 货号 | 5600/1 |
| 供应商 | Tocris |
| 生物活性 | Potent bombesin receptor subtype 3 (BRS-3; BB3) agonist (IC50 = 2.52 nM). Also GRPR (BB1) and NMBR (BB2) agonist (IC50 values are 0.26 and 1.55 nM respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1133.32 |
| 分子式 | C57H76N14O11 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | YQWAVAHFX (Modifications: Tyr-1= D-Tyr, Ala-6 = β-Ala, X = Nle, Nle-9 = C-terminal amide) |
| 参考文献 | Gonzálezet al (2015) Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes Int.J.Mol.Med. 35 925. PMID: 25653074. Moodyet al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55. PMID: 25554218. Morenoet al (2013) Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J.Pharmacol.Exp.Ther. 347 100. PMID: 23892571. |