| 货号 | 5795/1 |
| 供应商 | Tocris |
| 生物活性 | CXCR4 allosteric agonist (EC50 = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards Gi proteins over G13andβ-arrestin. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2256.82 |
| 分子式 | C104H178N26O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | MGYQKKLRSMTDKYRL (Modifications |
| 参考文献 | Planesaset al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 60 1. PMID: 26080355. Quoyeret al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 110 E5088. PMID: 24309376. Tchernychevet al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 107 22255. PMID: 21139054. |