| 货号 | 3964/10 |
| 别名 | (3S)-Spiro[1-azabicyclo[2.2.2]octan |
| 供应商 | Tocris |
| 生物活性 | Selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). CNS penetrant after systemic administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 218.68 |
| 分子式 | C9H14N2O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 100 mM in water |
| 参考文献 | Huanget al (2010) Activation of presynaptic α7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br.J.Pharmacol. 159 554. PMID: 20105181. Grotticket al (2000) Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. J.Pharmacol.Exp.Ther. 294 1112. PMID: 10945867. Mullenet al (2000) (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. J.Med.Chem. 43 4045. PMID: 11063601. |