| 货号 | 2457/10 |
| 别名 | 12,13-Dihydro-5H-indolo[2,3-a]pyrro |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM). Also active against CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro(IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro(IC50 = 200 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 325.32 |
| 分子式 | C20H11N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 118458-54-1 |
| 参考文献 | Sanchez-Martinezet al (2003) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 3835. PMID: 14552791. Zhuet al (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 1231. PMID: 12657252. Slateret al (1999) Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 7 1067. PMID: 10428375. |