| 货号 | 14493-100ug |
| 描述 | Macrophage Migration Inhibitory Factor (MIF) is a small, pro-inflammatory cytokine. MIF signaling is important in septic shock, arthritis, colitis, and cardiovascular diseases.1 MIF counteracts glucocorticoid signaling, which would otherwise inhibit inflammation. Secreted MIF binds to CD74 receptors, which then couple to CD44, during monocyte recruitment.2 In addition to CD44 binding, MIF is an enzymatically active keto-enol tautomerase that is inhibited by isothiocyanates such as sulforaphane.3 Overexpression of MIF has been seen in several cancers. MIF overexpression has been shown to promote hypoxia induced HIF-1α stabilization leading to changes in the tumor microenvironment, including stimulation of angiogenesis and neovascularization.4 |
| 别名 | Macrophage Migration Inhibitory Factor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zernecke, A.,Bernhagen, J. and Weber, C. Macrophage migration inhibitory factor in cardiovascular disease. Circulation 117(12), 1594-1602 (2008). 2.Leng, L. and Bucala, R. Insight into the biology of macrophage migration inhibitory factor (MIF) revealed by the cloning of its cell surface receptor. Cell Research 16(2), 162-168 (2006). 3.Healy, Z.R.,Liu, H.,Holtzclaw, W.D., et al. Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: A potential biomarker for anti-inflammatory intervention. Cancer Epidemiology, Biomarkers & Prevention 20(7), 1516-1523 (2011). 4.Rendon, B.E.,Willer, S.S.,Zundel, W., et al. Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation. Exp.Mol.Pathol. 86(3), 180-185 (2009). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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