| 货号 | 6019/10 |
| 别名 | L-Isoleucyl-L-prolyl-L-isoleucine; Ile-Pro-Ile |
| 供应商 | Tocris |
| 生物活性 | Dipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 341.45 |
| 分子式 | C17H31N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 序列号 | IPI |
| 参考文献 | Leeet al (2016) Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 6 29393. PMID: 27381080. Limet al (2015) Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 30 759. PMID: 26552451. Juillerat-Jeanneretet al (2014) Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 57 2197. PMID: 24099035. |