| 货号 | 5032/10 |
| 别名 | (8R)-7-Acetyl-5-(4-aminophenyl)-8,9 |
| 供应商 | Tocris |
| 生物活性 | Non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 337.37 |
| 分子式 | C19H19N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Belayevet al (2001) Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 18 1031. PMID: 11686490. Borowiczet al (2000) The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam. Naunyn-Schmied.Arch.Pharmacol. 361 629. PMID: 10882038. Czuczwaret al (1998) LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 359 103. PMID: 9832379. |