| 货号 | 5124/10 |
| 别名 | 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1 |
| 供应商 | Tocris |
| 生物活性 | High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 217.29 |
| 分子式 | C11H11N3S |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol |
| 参考文献 | Chamoun-Emanuelliet al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687. PMID: 24217696. Ghebremariamet al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69. PMID: 24135074. Bircket al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 1229334. |