| 货号 | 5206/10 |
| 别名 | 4-[Bis(1,3-benzodioxol-5-yl)methyl] |
| 供应商 | Tocris |
| 生物活性 | Potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 0.4 nM). Exhibits >13,000 and ~630-fold selectivity for MAGL over FAAH and ABHD6 respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 434.44 |
| 分子式 | C23H22N4O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Laitinenet al (2014) Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol.Pharmacol. 85 510. PMID: 24368842. Aaltonenet al (2013) Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem.Biol. 20 379. PMID: 23521796. |