| 货号 | 5353/1 |
| 供应商 | Tocris |
| 生物活性 | Selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1161.45 |
| 分子式 | C55H96N14O13 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | KQIEIKKFK |
| 参考文献 | Abudaraet al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 8. PMID: 25374505. Boengleret al (2013) Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 4. PMID: 23760924. Wanget al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309. PMID: 23184389. |