| 货号 | 5449/10 |
| 别名 | 2-[1-[4-[2-(4-Chlorophenoxy)acetyl] |
| 供应商 | Tocris |
| 生物活性 | Antitumor agent; selective for cells expressing oncogenic RAS. Also Ferroptosis activator; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 547.04 |
| 分子式 | C30H31ClN4O4 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Dixonet al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060. PMID: 22632970. Yagodaet al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864. PMID: 17568748. Dolmaet al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285. PMID: 12676586. |