| 货号 | 4787/10 |
| 别名 | N-[4-Chloro-2-[(1,3-dihydro-1,3-dio |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator at mGlu1 and mGlu5; thought to act at a novel allosteric site. Potentiates mGlu5 responses by a mechanism distinct from that of VU 29 (Cat. No. 4458). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 406.82 |
| 分子式 | C22H15ClN2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Chenet al(2008)N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 73 909. PMID: 18056795. O'Brienet al (2004) A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J.Pharmacol.Exp.Ther. 309 568. PMID: 14747613. |