| 货号 | 3633/10 |
| 别名 | α,β-Methyleneadenosine 5'-diphosphate monosodium salt |
| 供应商 | Tocris |
| 生物活性 | Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 447.21 |
| 分子式 | C11H16N5NaO9 |
| 可溶性/溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
| 参考文献 | Kuret al (2014) Purinergic control of vascular tone in the retina. J.Physiol. 592 491. PMID: 24277867. Niemeläet al (2008) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 38 2718. PMID: 18825744. Ujházyet al (1996) Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer. 68 493. PMID: 8945621. |