Estradiol 17-(β-D-Glucuronide) (sodium salt)
货号：
16156-25mg 基本售价：
2898.0 元 规格：
25 mg
产品信息
概述| 货号 | 16156-25mg |
| 描述 | Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1 It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km = 75 µM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2 In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transport via MRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) (E23G; Item No. 16155).2,3E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.2 |
| 别名 | E217G;β-Estradiol 17-(β-D-Glucuronide);17β-Estradiol 17-(β-D-Glucuronide);17β-Oestradiol 17-(β-D-Glucuronide); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Loe, D.W.,Almquist, K.C.,Cole, S.P., et al. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. The Journal of Biological Chemisty 271(16), 9683-9689 (1996).
2.Gerk, P.M.,Li, W. and Vore, M. Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide. Drug Metabolism and Disposition 32(10), 1139-1145 (2004).
3.Gerk, P.M.,Li, W.,Megaraj, W., et al. Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. Journal of Pharmacology and Experimental Therapeutics 320(2), 893-899 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 470.5 |
| 分子式 | C24H31O8 • Na |
| CAS号 | 15087-02-2 |
| 稳定性 | ≥ 2 years |
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