Leptomycin A
货号：
21762-500ug 基本售价：
2828.0 元 规格：
500 ug
产品信息
概述| 货号 | 21762-500ug |
| 描述 | Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.1 Leptomycin A inhibits Rev translocation, though less potently than leptomycin B (Item No. 10004976) with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours.2 Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent. |
| 别名 | NSC 369326; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kudo, N.,Wolff, B.,Sekimoto, T., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242, 540-547 (1998).
2.Wang, Y.,Ponelle, M.,Sanglier, J.-J., et al. Novel leptomycins from a Streptomyces strain A92-308902: Inhibitors of the nucleo-cytoplasmic translocation of the HIV-1 regulatory protein rev. Helv. Chim. Acta. 80(7), 2157-2167 (1997).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 526.7 |
| 分子式 | C32H46O6 |
| CAS号 | 87081-36-5 |
| 稳定性 | ≥ 2 years |
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