| 货号 | 3322/10 |
| 别名 | 7-Chloro-2,3-dihydro-2-(4-methoxy-2 |
| 供应商 | Tocris |
| 生物活性 | NMDA receptor antagonist; acts at glycine site. Neuroprotective; reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 383.79 |
| 分子式 | C19H14ClN3O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 20 mM in 1eq. NaOH |
| 参考文献 | Tatlisumak (2000) A glycine antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta.Neurochir.Suppl. 76 331. PMID: 11450037. Takano (1997) Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 28 1255. PMID: 9183359. Bare (1993) Pyridazino[4,5-b]quinolinediones: a series of novel glycine site NMDA antagonists with potent in vitro and in vivo properties. Abstracts of Papers of the ACS 205 79. Abstract.. |