| 货号 | 2465/10 |
| 别名 | N-Cyclohexyl-2'-O-methyladenosine |
| 供应商 | Tocris |
| 生物活性 | Potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 363.41 |
| 分子式 | C17H25N5O4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO |
| CAS号 | 130714-47-5 |
| 参考文献 | Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247. PMID: 16518376. Ishikawaet al (1998) Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 39 3. PMID: 9597368. Wagneret al (1995) General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res. 34276. |