| 货号 | 1393/10 |
| 别名 | 3-Methyl-2-phenyl-N-[(1S)-1-phenylp |
| 供应商 | Tocris |
| 生物活性 | Potent and selective non-peptide NK3 receptor antagonist (Ki values are 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors respectively). Antihypertensive in vivo. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 380.48 |
| 分子式 | C26H24N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 174635-69-9 |
| 参考文献 | De Brito Gariepy and Couture (2010) Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic mechanism in the ventral tegmental area of spontaneously hypertensive rats. Br.J.Pharmacol. 161 1868. PMID: 20804497. Sarauet al (2000) Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J.Pharmacol.Exp.Ther. 295 373. PMID: 10992004. Medhurstet al(1997)In vitroandin vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br.J.Pharmacol. 122 469. PMID: 9351503. |