| 货号 | 1618/500U |
| 别名 | PYY 3-36 |
| 供应商 | Tocris |
| 生物活性 | Y2 selective agonist. IC50 values are 0.11 and 1050 nM for inhibition of 125I-PYY binding to Y2 and Y1 receptors respectively. Inhibits food intake and reduces weight gain in vivo. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3980.4 |
| 分子式 | C176H272N52O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | AKPEAPGEDASPEELSRYYASLRHYLNLVT (Modifications: Tyr-34 = C-terminal amide) |
| 参考文献 | Nonakaet al (2003) Characterization of blood-brain barrier permeability to PYY3-36 in the mouse. J.Pharmacol.Exp.Ther. 306 948. PMID: 12750431. Batterhamet al (2002) Gut hormone PYY3-36 physiologically inhibits food intake. Nature 418 650. PMID: 12167864. Keireet al (2000) Primary structures of PYY, [Pro34]PYY and PYY-(3-36) confer different conformations and receptor selectivity. Am.J.Physiol.Gastrointest.Liver Physiol. 279 G126. PMID: 10898754. |