| 货号 | 3801/1 |
| 别名 | myr-pep2m |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable, myristoylated form of pep2m (Cat. No. 1595). Peptide inhibitor of the interaction between the C-terminus of the GluR2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1383.8 |
| 分子式 | C63H118N18O14S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | KRMKVAKNAQ (Modifications: Lys-1 = N-terminal Myr) |
| 参考文献 | Yaoet al (2008) PKMz maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. J.Neurosci. 28 7820. PMID: 18667614. Luscheret al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649. PMID: 10595516. Luthiet al (1999) Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron 24 389. PMID: 10571232. Noelet al (1999) Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron 23 365. PMID: 10399941. Nishimuneet al (1998) NSF binding to GluR2 regulates synaptic transmission. Neuron 21 87. PMID: 9697854. |