| 货号 | 3691/10 |
| 别名 | (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-n |
| 供应商 | Tocris |
| 生物活性 | Glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 289.41 |
| 分子式 | C15H31NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 81117-35-3 |
| 参考文献 | Anderssonet al (2004) Inhibition of glycogen breakdown by imino sugars in vitroandin vivo. Biochem.Pharmacol. 67 697. PMID: 14757169. Melloret al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867. PMID: 15128289. Sawkaret al (2002) Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 9915428. |