| 货号 | 4041/10 |
| 别名 | N-[2-(2-Furanyl)-8-propyl-8H-pyrazo |
| 供应商 | Tocris |
| 生物活性 | Potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 423.44 |
| 分子式 | C21H20N8O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Varaniet al (2010) Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 160 101. PMID: 20331607. Gessiet al (2004) Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 65 711. PMID: 14978250. Baraldiet al (1999) Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 42 4473. PMID: 10579811. |