| 货号 | 2507/10 |
| 别名 | (αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-m |
| 供应商 | Tocris |
| 生物活性 | Potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 500.63 |
| 分子式 | C24H36N2O2.C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 244277-89-2 |
| 参考文献 | Mitsuyaet al (2000) Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg.Med.Chem. 8 825. PMID: 10819171. Mitsuyaet al (1999) Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129. Bioorrg.Med.Chem.Lett. 92037. Mitsuyaet al (1999) J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg.Med.Chem. 7 2555. PMID: 10632066. |