| 货号 | 1770/10 |
| 别名 | (7aS,13aS)-13,13a-Dihydro-9,10-dime |
| 供应商 | Tocris |
| 生物活性 | Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 394.42 |
| 分子式 | C23H22O6 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 522-17-8 |
| 参考文献 | Chunet al (2003) Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J.Natl.Cancer Inst. 95 291. PMID: 12591985. Fang and Casida (1998) Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc.Natl.Acad.Sci.U.S.A. 95 3380. PMID: 9520374. Udeaniet al (1997) Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 57 3424. PMID: 9270008. Takatsukiet al (1969) Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses. Appl.Microbiol. 18 660. PMID: 4312925. |