| 货号 | 3520/500U |
| 供应商 | Tocris |
| 生物活性 | Endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2197.61 |
| 分子式 | C93H157N27O2 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | GLSKGCFGLKLDRIGSMSGLGC (Modifications: Disulfide bridge between 6 - 22) |
| 参考文献 | Rose and Giles (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 586 353. PMID: 18006579. Pejchalovaet al (2007) C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 92 210. PMID: 17681481. Sugaet al (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130 229. PMID: 1309330. |