| 货号 | 5590/10 |
| 别名 | 4-[4-[(Dimethylamino)methyl]-2,5-di |
| 供应商 | Tocris |
| 生物活性 | Potent and selective BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 353.41 |
| 分子式 | C20H23N3O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming |
| 参考文献 | Karim and Schönbrunn (2016) An Advanced Tool To Interrogate BRD9. J.Med.Chem. 59 4459. PMID: 27120693. Martinet al (2016) Structure-based design of an in vivo active selective BRD9 inhibitor J.Med.Chem. 59 4462. PMID: 26914985. |