| 货号 | 1757/10 |
| 别名 | N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)- |
| 供应商 | Tocris |
| 生物活性 | Selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 429.92 |
| 分子式 | C24H24FNO3.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 571147-18-7 |
| 参考文献 | Lipinaet al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54. PMID: 15759151. Atkinsonet al (2001) ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol.Pharmacol. 60 1414. PMID: 11723250. |