Brevetoxin B
货号：
10011498-100ug 基本售价：
2786.0 元 规格：
100 ug
产品信息
概述| 货号 | 10011498-100ug |
| 描述 | Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.1,2 Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.2 |
| 别名 | Brevetoxin 2;BTX-B;GbTx-2;PbTx-2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Atchison, W.D.,Luke, V.S.,Narahashi, T., et al. Nerve membrane sodium channels as the target site of brevetoxins at neuromuscular junctions. British Journal of Pharmacology 89(4), 731-738 (2016).
2.Gawley, R.E.,Rein, K.S.,Jeglitsch, G., et al. The relationship of brevetoxin “length” and A-ring functionality to binding and activity in neuronal sodium channels. Chemistry & Biology 2(8), 533-541 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 895.1 |
| 分子式 | C50H70O14 |
| CAS号 | 79580-28-2 |
| 稳定性 | ≥ 2 years |
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