CBHA
货号：
13172-25mg 基本售价：
2758.0 元 规格：
25 mg
产品信息
概述| 货号 | 13172-25mg |
| 描述 | Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively.1 CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture (0.5-4.0 μM)2 and completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/kg.3 The efficacy of CBHA for suppressing tumor growth in mice is enhanced by the addition of retinoic acid.3 |
| 别名 | Histone Deacetylase Inhibitor II;m-Carboxycinnamic Acid bis-Hydroxamide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Richon, V.M.,Emiliani, S.,Verdin, E., et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proceedings of the National Academy of Sciences of the United States of America 95, 3003-3007 (1998).
2.Glick, R.D.,Swendeman, S.L.,Coffey, D.C., et al. Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Research 59, 4392-4399 (1999).
3.Coffey, D.C.,Kutko, M.C.,Glick, R.D., et al. The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid. Cancer Research 61, 3591-3594 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 222.2 |
| 分子式 | C10H10N2O4 |
| CAS号 | 174664-65-4 |
| 稳定性 | ≥ 2 years |
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