| 货号 | 5870/10 |
| 别名 | EMD121974 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of integrins αvβ3andαvβ5(IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 588.66 |
| 分子式 | C27H40N8O7 |
| 可溶性/溶解性 | Soluble to 10 mg/ml in water |
| 序列号 | RGDFV (Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclizedl) |
| 参考文献 | Alghisiet al (2009) The integrin antagonist cilengitide activates αvβ3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS One 4 e4449. PMID: 19212436. Monnieret al (2008) CYR61 and αvβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res. 68 7323. PMID: 18794119. |