| 货号 | 5296/1 |
| 别名 | [Pen5,DTrp7,Orn8]hU-II(4-11) |
| 供应商 | Tocris |
| 生物活性 | Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1075.26 |
| 分子式 | C51H66N10O12 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7) |
| 参考文献 | Carotenutoet al (2014) Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J.Med.Chem. 57 5965. PMID: 24992374. Patacchiniet al (2003) Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br.J.Pharmacol. 140 1155. PMID: 14645137. |