| 货号 | 1406/1 |
| 别名 | (2E,4E,6R)-7-(4-(Dimethylamino)phen |
| 供应商 | Tocris |
| 生物活性 | Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 302.37 |
| 分子式 | C17H22N2O3 |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 58880-19-6 |
| 参考文献 | Durcova-Hillset al (2008) Reprogramming primordial germ cells into pluripotent stem cells. PloS ONE 3 e3531. PMID: 18953407. Vigushinet al (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res. 7 971. PMID: 11309348. Whartonet al (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem. 275 33981. PMID: 10945992. Yoshidaet al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivoandin vitro by trichostatin A. J.Biol.Chem. 265 17174. PMID: 2211619. |