| 货号 | 1186/100U |
| 别名 | Pituitary Adenylate Cyclase-Activating Polypeptide 1-38 |
| 供应商 | Tocris |
| 生物活性 | Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP) but with a greater potency for stimulation of adenylyl cyclase. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4535 |
| 分子式 | C203H331N63O |
| 可溶性/溶解性 | Soluble to 0.90 mg/ml in water |
| 序列号 | HSDGIFTDSYSRYRKQMAVKKYLAAVLGKR (Modifications: Lys-38 = C-terminal amide) |
| 参考文献 | Lazaroviciet al (1998) The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21ras G protein, and pp60c-src cytoplasmic tyrosine kinase. Mol.Pharmacol. 54 547. PMID: 9730914. Michelet al (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143. PMID: 9549761. Rawlingset al (1994) Pituitary adenylate cyclase-activating polypeptide increase [Ca2+]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism. J.Biol.Chem. 269 5680. PMID: 7907085. |