| 货号 | 2430/1 |
| 别名 | N-[4-[2(R)-Amino-3-mercaptopropyl]a |
| 供应商 | Tocris |
| 生物活性 | CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells. |
| 运输条件 | Dry Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 593.66 |
| 分子式 | C27H33N3O3S.CF3CO2H |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 180977-44-0 |
| 参考文献 | Porcuet al (2010) A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics. Mol.Cancer 9 197. PMID: 20653956. Kusamaet al (2003) Selective inhibition of cancer cell invasion by a geranylgeranyltransferase inhibitor. Clin.Exp.Meta. 20561. Miquelet al (1997) GGTI-298 induces G0-G1 block and apoptosis whereas FTI-227 causes G2-M enrichment in A549 cells. Cancer Res. 57 1846. PMID: 9157972. McGuireet al (1996) Platelet-derived growth factor receptor tyrosine kinase phosphorylation requires protein geranylgeranylation but not farnesylation. J.Biol.Chem. 271 27402. PMID: 8910319. |