| 货号 | 3993/1 |
| 别名 | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)- |
| 供应商 | Tocris |
| 生物活性 | Vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 454.68 |
| 分子式 | C30H46O3 |
| 可溶性/溶解性 | Soluble in DMSO and in ethanol |
| CAS号 | 134404-52-7 |
| 参考文献 | Bhatiaet al (2009) EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. Mol.Cancer Ther. 8 1787. PMID: 19584236. Luet al (2008) Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. Mol.Cancer Ther. 7 1268. PMID: 18483314. Ormerodet al (2008) The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp.Lung.Rs. 34155. Hoyer-Hansenet al (2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 12 1297. PMID: 15905882. Abdaimiet al (1999) Reversal of hypercalcaemia with the vitamin D analogue EB1089 in a human model of squamous cancer. Cancer Res, 593325. |