| 货号 | 5062/1 |
| 供应商 | Tocris |
| 生物活性 | Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1200.36 |
| 分子式 | C48H73N13O17 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | CNPMGYTKEGC (Modifications: Disulfide bridge between 1 - 11) |
| 参考文献 | Constandilet al (2012) Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579. PMID: 22560237. Cazorlaet al (2010) Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice. PLoS One 5 e9777. PMID: 20333308. |