| 货号 | 1623/1 |
| 别名 | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo. Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 411.63 |
| 分子式 | C27H41NO2 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol |
| CAS号 | 4449-51-8 |
| 参考文献 | Baret al (2007) Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25 2524. PMID: 17628016. DAmouret al (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat.Biotechnol. 24 1392. PMID: 17053790. Scott (2003) Cancer: a twist in a hedgehog's tale. Nature 425 780. PMID: 14574396. Chenet al (2002) Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 16 2743. PMID: 12414725. |