| 货号 | 1626/100U |
| 别名 | (1R)-2-[12-[(2R)-2-(Benzoyloxy)prop |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro(IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 790.76 |
| 分子式 | C44H38O14 |
| 可溶性/溶解性 | Soluble in DMSO and in ethanol |
| 参考文献 | Matsuzaki and Darcha (2013) In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One 8 e61690. PMID: 23626717. Auet al (2006) Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 85 92. PMID: 16829117. Pollack and Kawecki (1997) The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 31 255. PMID: 9049854. Kobayashiet al (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm. 159548. |