| 货号 | 15477-5mg |
| 描述 | Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.1,2 Cyclosporin D displays about 10% lower immunosuppressant activity than cyclosporin A.3,4 Cyclosporin D has been used as an internal standard for the quantification of cyclosporin A.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jorgensen, K.A.,Koefoed-Nielsen, P.B. and Karamperis, N. Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus. Scandinavian Journal of Immunology 57(2), 93-98 (2003). 2.Vollenbroeker, B.,Koch, J.H.,Fobker, M., et al. Determination of cyclosporine and its metabolites in blood via HPLC-MS and correlation to clinically important parameters. Transplantation Proceedings 37(4), 1741-1744 (2005). 3.von Wartburg, A. and Traber, R. Cyclosporins, fungal metabolites with immunosuppressive activities. Prog.Med.Chem. 25, 1-33 (1988). 4.Copeland, K.R.,Yatscoff, R.W. and McKenna, R.M. Immunosuppressive activity of cyclosporine metabolites compared and characterized by mass spectroscopy and nuclear magnetic resonance. Clinical Chemistry 36(2), 225-229 (1990). 5.Kaiser, P.,Akerboom, T.,Wood, W.G., et al. A new approach for the determination of immunosuppressive drugs using HPLC-MS/MS and Cs+ adducts. Ger.Med.Sci. 4, 1-12 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1216.7 |
| 分子式 | C63H113N11O12 |
| CAS号 | 63775-96-2 |
| 稳定性 | ≥ 2 years |
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